“What role does the immune system play in the surveillance and prevention of tumor formation and spread? What is the tumor microenvironment and why is it so important? Can inflammation promote tumor formation and, if so, how? How can cancer cells survive given substantial genomic instability? What happens with cellular metabolism in tumors and for what benefit does cancer cells deregulate it?
What are cancer stem cells and why is it so crucial to get rid of them? Can cancer cells change into cancer stem cells or vice versa through phenotypic plasticity? What does it mean for tumors to be genetically heterogeneous and what parts of tumors are most diverse? What are some important aspects of signaling interactions during tumor progression?”