“There are many different kinds of cancer and there is a huge variation in genotypes within a single kind of cancer. So how can we get a grasp of the complexities of cancer without getting lost in the details? Are there some unifying principles of cancer molecular biology that can be discerned from the data?
How can cancer cells grow even in the absence of external growth stimuli? Why are they immune to anti-growth signals from their environment? How can they avoid programmed cell death? How can they make sure they have a steady supply of nutrients? How can they move through tissue and create daughter tumors in completely different parts of the body? A seminal review paper exploring these issues emphasizes six such key principles.”